Sporadic Jakob-Creutzfeldt Disease: A Diagnostic Challenge in Low-Income Countries
Solorza-Ortiz Emmanuel1, Rincón-Guevara Gabriela Paulina1, Miranda-Hernández Alexis1, Contreras-Tejeida Cynthia Daniela1, Virviescas-Peña Jairo Andrés1, Guancha-Aza Leidy Johana1, Ortiz-Robles Arely1, Popoca-Rodríguez Ignacio1, Cedillo-Mondragón José Benjamín1, Merino-Aguilera Patricio Alexander1, Zacarías-Merling José Ryan1, García-Moreno Citlali Elizabeth1, Franyutti-Prado Kenia Fernanda1, Avecilla-Bonilla Denise Alejandra1, Alfaro-Tapia Claudia Elisa1, García-Toribio Martha Guadalupe2*
1Service of Neurology, Hospital General de Mexico Dr. Eduardo Liceaga, Mexico.
2Neurophysiology and Epileptology department, Hospital General de Mexico Dr. Eduardo Liceaga, Mexico.
*Corresponding Author: García-Toribio Martha Guadalupe, Neurophysiology and epileptology department, Hospital General de Mexico Dr. Eduardo Liceaga, Mexico. ORCID 0000-0002-4303-1208
https://doi.org/10.58624/SVOANE.2025.06.011
Received: May 24, 2024
Published: April 03, 2025
Citation: Solorza-Ortiz E, Rincon-Guevara GP, Miranda-Hernandez A, Contreras-Tejeida CD, Virviescas-Pena JA, Guancha-Aza LJ, Ortiz-Robles A, Popoca-Rodrí guez I, Cedillo-Mondragon JB, Merino-Aguilera PA, Zacarías-Merling JR, García-Moreno CE, Franyutti-Prado KF, Avecilla-Bonilla DA, Alfaro-Tapia CE, García-Toribio MG. Sporadic Jakob-Creutzfeldt Disease: A Diagnostic Challenge in Low-Income Countries. SVOA Neurology 2025, 6:2, 55-61. doi. 10.58624/SVOANE.2025.06.011
Abstract
Jakob-Creutzfeldt disease (JCD) is a fatal degenerative brain disorder caused by prion proteins. This condition belongs to the group of transmissible spongiform encephalopathies affecting people worldwide, with an incidence of 1 case per million per year. Due to the heterogeneity of symptoms and signs, prion diseases are considered a diagnostic and therapeutic challenge, due to the nonspecificity of the clinical presentation. We present three cases initially diagnosed with other conditions, subsequently establishing the definitive diagnosis of JCD. Next, a state-of-the-art review regarding this disorder will be carried out, and its implications in differential diagnosis and epidemiological surveillance.
Keywords: Transmissible spongiform encephalopathies; Prion disease; Creutzfeldt–Jakob disease; Rapidly progressing dementia.
